Simcryocluster: a semantic similarity clustering method of cryo-EM images by adopting contrastive learning
Abstract Background Cryo-electron microscopy (Cryo-EM) plays an increasingly important role in the determination of the three-dimensional (3D) structure of macromolecules.In order to achieve 3D reconstruction results close to atomic resolution, 2D single-particle image classification is not only conducive to single-particle selection, but also a ke